USDA Confirms Atypical Bovine Spongiform Encephalopathy in Florida Cows

The Florida Department of Agriculture and Consumer Services announced on Wednesday that it is working closely with the U.S. Department of Agriculture regarding an atypical case of Bovine Spongiform Encephalopathy (BSE), a neurologic disease of cattle, in a six-year-old, mixed-breed beef cow in Florida. This animal never entered slaughter channels and at no time presented a risk to the food supply, or to human health in the United States. This form of BSE is not contagious.

“This detection shows just how well our surveillance system works. We’re grateful to our partners at the U.S. Department of Agriculture who work alongside us day in and day out to conduct routine surveillance and protect consumers,” stated Commissioner of Agriculture Adam H. Putnam.

Atypical BSE is different than Classical BSE, and it generally occurs in older cattle and seems to arise rarely and spontaneously in all cattle populations.

USDA Animal and Plant Health Inspection Service’s (APHIS) National Veterinary Services Laboratories (NVSL) confirmed that this cow was positive for atypical H-type BSE.  The animal was tested as part of APHIS’s routine surveillance of cattle that are deemed unsuitable for slaughter. APHIS and Florida veterinary officials are gathering more information on the case.

BSE is not contagious and exists in two types – classical and atypical.  Classical BSE is the form that occurred primarily in the United Kingdom, beginning in the late 1980’s, and it has been linked to variant Creutzfeldt-Jakob disease (vCJD) in people. The primary source of infection for classical BSE is feed contaminated with the infectious prion agent, such as meat-and-bone meal containing protein derived from rendered infected cattle.  Regulations from the Food and Drug Administration (FDA) have prohibited the inclusion of mammalian protein in feed for cattle and other ruminants since 1997 and have also prohibited high risk tissue materials in all animal feed since 2009.

The United States has a longstanding system of interlocking safeguards against BSE that protects public and animal health in the United States. Additionally, the BSE surveillance program allows USDA to detect the disease if it exists at very low levels in the U.S. cattle population.

 

1 COMMENT

  1. ”Atypical BSE is different, and it generally occurs in older cattle, usually 8 years of age or greater. It seems to arise rarely and spontaneously in all cattle populations.”

    FALSE!

    ”The primary source of infection for classical BSE is feed contaminated with the infectious prion agent, such as meat-and-bone meal containing protein derived from rendered infected cattle. Regulations from the Food and Drug Administration (FDA) have prohibited the inclusion of mammalian protein in feed for cattle and other ruminants since 1997 and have also prohibited high risk tissue materials in all animal feed since 2009.”

    FALSE!

    LET’S REVIEW RECENT AND PAST SCIENCE THAT SHOWS THE ABOVE TWO STATEMENTS ARE FAR FROM TRUE;

    P98 The agent of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism transmits after oronasal challenge

    Greenlee JJ (1), Moore SJ (1), and West Greenlee MH (2)

    (1) United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Virus and Prion Research Unit, Ames, IA, United States (2) Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, United States.

    In 2006, a case of H-type bovine spongiform encephalopathy (BSE) was reported in a cow with a previously unreported prion protein polymorphism (E211K).

    The E211K polymorphism is heritable and homologous to the E200K mutation in humans that is the most frequent PRNP mutation associated with familial Creutzfeldt-Jakob disease.

    Although the prevalence of the E211K polymorphism is low, cattle carrying the K211 allele develop H-type BSE with a rapid onset after experimental inoculation by the intracranial route.

    The purpose of this study was to investigate whether the agents of H-type BSE or H-type BSE associated with the E211K polymorphism transmit to wild type cattle or cattle with the K211 allele after oronasal exposure.

    Wild type (EE211) or heterozygous (EK211) cattle were oronasally inoculated with either H-type BSE from the 2004 US Htype BSE case (n=3) or from the 2006 US H-type case associated with the E211K polymorphism (n=4) using 10% w/v brain homogenates.

    Cattle were observed daily throughout the course of the experiment for the development of clinical signs.

    At approximately 50 months post-inoculation, one steer (EK211 inoculated with E211K associated H-BSE) developed clinical signs including inattentiveness, loss of body condition, weakness, ataxia, and muscle fasciculations and was euthanized.

    Enzyme immunoassay confirmed that abundant misfolded protein was present in the brainstem, and immunohistochemistry demonstrated PrPSc throughout the brain.

    Western blot analysis of brain tissue from the clinically affected steer was consistent with the E211K H-type BSE inoculum.

    With the experiment currently at 55 months post-inoculation, no other cattle in this study have developed clinical signs suggestive of prion disease.

    This study demonstrates that the H-type BSE agent is transmissible by the oronasal route.

    These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains. =====

    see updated science on typical and atypical BSE;

    WEDNESDAY, AUGUST 29, 2018

    USDA Announces Atypical Bovine Spongiform Encephalopathy Detection USDA 08/29/2018 10:00 AM EDT

    http://bse-atypical.blogspot.com/2018/08/usda-announces-atypical-bovine.html

    kind regards, terry

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